CytoChip Cancer SNP
In addition to detection of copy number imbalance at a high resolution, SNP microarrays incorporate SNP calling to enable the detection of copy number neutral LOH/UPD (loss of heterozygosity/uniparental isodisomy) in the same assay.
BlueGnome supply two CytoChip SNP platforms for two applications, CytoChip Oligo SNP 4x180K and CytoChip Cancer SNP 4x180K.
CytoChip Cancer SNP incorporates the BlueGnome cancer design with probes targeted to 670 cancer-related genes. More than 20,000 oligo probes cover genome regions important in cancer with an exon-focused design. The backbone genome probes enable, on average, 90 Kb imbalances to be detected. CytoChip Cancer SNP includes 60,000 SNP specific probes, spaced across the genome, providing approximately 5 Mb acquired LOH/UPD detection.
Fully genotyped SNPRef reference DNA (male and female) for use with the CytoChip Oligo SNP and CytoChip Cancer SNP microarrays is now available to order. The corresponding genotype files required for analysis are available for download.
Complementary BlueFuse software licenses deliver fully automated array processing, including sophisticated algorithms for the identification and reporting of regions of copy number imbalance alongside regions of LOH. Cancer specific tracks, now available in the cancer annotation database, aide in the interpretation of cases by comparing to progenetix, COSMIC and Mitelman databases. All results are stored in a powerful SQL database through which regions associated with specific characteristics may be easily identified, confirmed, exported and shared with collaborators.
CytoChip Cancer SNP may be ordered in boxes of four slides, complete with gaskets, or as a pack complete with quality controlled labelling systems and Human COT DNA.
See also
Applications in cancer.
CytoChip Cancer for disease focused cancer microarrays without SNP probes.
For Research Use Only. Not for use in diagnostic procedures
